Resumen Introducción Los adolescentes que practican deportes tienen mejores indicadores de salud mental. Objetivo Analizar la asociación entre los diferentes tipos de actividad física (ejercicio sistematizado, deportes individuales y colectivos), la salud mental y la ideación suicida en adolescentes. Método Se realizó un estudio transversal realizado con 666 adolescentes brasileños (14-19 años) que asisten a escuelas secundarias y fueron seleccionados mediante muestreo aleatorio por conglomerados. Los indicadores de salud mental analizados fueron evaluados a través del Cuestionario de Autoinforme y el Cuestionario de Fortalezas y Dificultades, incluyendo la ideación suicida. También obtuvimos información de la actividad física a través de cuestionarios. Resultados Hubo una mayor prevalencia relacionada con trastornos mentales (54.2% contra 32.5%), dificultades relacionadas con la salud mental (79.6% contra 48.4%) y pensamientos suicidas (22.9% contra 11.4%) en niñas que en niños (p < .001 para todos). Los chicos practicaban más deportes de equipo (41.0 contra 23.8), mientras que las chicas hacían más ejercicio (45.1 contra 26.5; p < .001). Discusión y conclusión La práctica de deportes de equipo ayuda en el desarrollo del espíritu colectivo, estimula la interacción social, desarrolla el razonamiento y la inteligencia emocional. Los niños que practican deportes de equipo tienen menos síntomas de trastornos mentales comunes, menos problemas de salud mental y menos ideación suicida en comparación con los niños físicamente inactivos.

Abstract Introduction Adolescents who practice sports have better mental health indicators. Objective To analyze the association between different types of physical activity (systematized exercise, individual, and collective sports), mental health, and suicidal ideation in adolescents. Method We conducted a cross-sectional study with 666 Brazilian adolescents (14-19 y.o.) attending high schools and selected using random cluster sampling. The mental health indicators analyzed were evaluated through the Self Reporting Questionnaire and the Strengths and Difficulties Questionnaire, including suicidal ideation. We also obtained physical activity information through questionnaires. Results There was a higher prevalence related to mental disorders (54.2% vs. 32.5%), difficulties related to mental health (79.6% vs. 48.4%), and suicidal thoughts (22.9% vs. 11.4%) in girls than in boys (p < .001 for all). The boys engaged in more team sports (41.0 vs. 23.8), whereas girls performed more exercise (45.1 vs. 26.5; p < .001). Discussion and conclusion The practice of team sports helps develop the collective spirit, stimulates social interaction, and develops reasoning and emotional intelligence. Boys who play team sports have fewer symptoms of common mental disorders, lower mental health problems, and less suicidal ideation than physically inactive boys.

Abstract Brazilian high school was modified having the National Common Curricular Base (BNCC) as the central axis for the curricular restructuring of each state. The research aims to analyze language comprehension in the curriculum of the state of Sergipe and reflect on possible implications for the teaching of Physical Education in high school. This is documentary-exploratory research with a qualitative approach, which works with the document of the state curriculum of Sergipe at the high school level. From the exploration of the material, the content analysis is carried out with the aid of the Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires (IRAMUTEQ) software, through the treatment of data by Descending Hierarchical Classification (CHD). By lexical analysis, four classes/categories were identified (“Language and modality”, “Institutional system”, “Youth” and “Expressions and their fields”). The analyses show that, by conceptualizing the notion of language, the document approaches the historical-socio-cultural approach to language. It also approaches the objects of knowledge through language expressions (oral, written, visual, etc.) specific to each subject and which, due to a vague position regarding the notion of language, does not place PE in the language area.

Resumo O Ensino Médio Brasileiro foi modificado tendo a Base Nacional Comum Curricular (BNCC) como eixo central para a reestruturação curricular de cada Estado. A pesquisa tem por objetivo analisar a compreensão de linguagem no currículo de Sergipe e refletir possíveis implicações no ensino da Educação Física (EF) no Ensino Médio. Trata-se de pesquisa documental-exploratória de abordagem qualitativa. O estudo trabalha com o currículo Estadual de Sergipe na etapa do Ensino Médio. A partir da exploração do material procede-se com a Análise de Conteúdo com o auxílio do software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires (IRAMUTEQ) através do tratamento dos dados por Classificação Hierárquica Descendente (CHD). Por análise lexical, foram identificadas quatro classes/categorias (“Linguagem e modalidade”, “Sistema institucional”, “Juventude” e “Expressões e seus campos”). As análises apontam que o documento, ao conceituar a noção de linguagem, se aproxima da abordagem histórico-sócio-cultural de linguagem. Traz também os objetos de conhecimentos por expressões de linguagem (oral, escrita, visual, etc.) específicas de cada disciplina e que, por posição vaga quanto à noção de linguagem, não situa o lugar da EF na área de linguagem.

ABSTRACT Objective: To analyze the social representations of nursing students about transsexuality and the health demands of transsexual people. Methods: Qualitative, descriptive research with undergraduate nursing students from a public university in Rio de Janeiro/Brazil. The data came from a semi-structured interview and lexical analysis using Alceste 2012 software. Results: Transsexuality was represented as a transgression, with the transsexual person being objectified as unnatural because they do not identify with their biological sex. Hormone therapy and sex reassignment surgeries were understood as the main demands, being anchored in a pathologizing and medicalizing health sphere. However, the theme is not addressed during graduation, generating unpreparedness for professional life. Final considerations: The need to update the academic curriculum, as well as the way of thinking about the care of transsexual people, is essential and urgent for an integral and equitable care.

RESUMEN Objetivo: Analizar las representaciones sociales de estudiantes de enfermería sobre la transexualidad y las demandas de salud de las personas transexuales. Métodos: Investigación cualitativa, descriptiva con estudiantes de graduación en enfermería de una universidad pública de Río de Janeiro/Brasil. Los datos provinieron de una entrevista semiestructurada y análisis léxico utilizando el software Alceste 2012. Resultados: La transexualidad fue representada como una transgresión, siendo objetivada la persona transexual como antinatural porque no se identifica con su sexo biológico. La terapia hormonal y las cirugías de reasignación de sexo fueron entendidas como las principales demandas, ancladas en un ámbito patologizante. ymedicalizando la salud. Sin embargo, el tema no es abordado durante la graduación, generando despreparación para la vida profesional. Consideraciones finales: La necesidad de actualizar el currículo académico, así como la forma de pensar la atención a las personas transexuales, es fundamental y urgente para una atención integral y equitativa.

RESUMO Objetivo: Analisar as representações sociais dos graduandos de enfermagem acerca da transexualidade e as demandas de saúde das pessoas transexuais. Métodos: Pesquisa qualitativa, descritiva, com 28 graduandos em enfermagem de uma universidade pública do Rio de Janeiro/Brasil. Realizou-se uma entrevista semiestruturada, no período de novembro de 2017 a março de 2018, e análise tipo lexical com auxílio do software Alceste 2012. Resultados: A transexualidade foi representada como uma transgressão, sendo a pessoa transexual objetivada como antinatural por não se identificar com seu sexo biológico. Terapia hormonal e cirurgias de redesignação sexual foram entendidas como as principais demandas, sendo ancoradas numa esfera patologizante e medicalizadora da saúde. A temática não é abordada durante a graduação, gerando despreparo para vida profissional. Considerações finais: Faz-se necessário ampliar as discussões sobre gênero na academia, tendo como propósito a transposição do imperativo da heteronormatividade, para que futuros enfermeiros estejam aparelhados para fornecer um cuidado integral e equânime.

ABSTRACT The use of smart devices is driving the growth of modern systems markets, resulting in more technological cities, cars, houses, and airplanes. Therefore, it is important to understand which smart technologies can support or even fulfill stakeholder needs and consequently enhance airplane operation and increase product competitiveness for airlines. This paper is the second of two-part series and has as its main objective the study of smart technologies that can be implemented on cabins of regional airplanes, from 60 to 120 seats, to comply with the needs and requirements pre-established on the first part of this series of articles. The integration of those technologies results in a “Smart Cabin” architecture which its purpose is to enhances the passenger experience by granting a new level of cabin comfort, customization, and connectivity that allows the reduction of airplane time on ground because of the real-time monitoring of airplane cabin components that enables the prediction of maintenance procedures; creates new profits and revenues opportunities for services, provides a more sustainable airplane operation and derived services, and creates new business opportunities for all companies that integrate regional aviation ecosystem.

ABSTRACT New technologies are increasingly being implemented in people’s daily lives and with the growth of smart devices around the globe, the users’ needs and demands have changed in favor of more technological cities, cars, houses, and airplanes. Therefore, it is important to define the stakeholder’s needs and requirements to understand which technologies, smart or not, can be implemented on the cabin to support or even fulfill stakeholder needs. Consequently, those technologies enhance airplane operation and increase product competitiveness for airlines. This paper is the first of a two-part series where design thinking tools are applied to establish high-level requirements based on the concept of a “Smart Cabin” for regional airplanes from 60 to 120 seats. To achieve this goal, a series of methods such as stakeholders’ studies, personas creation and user journey methods are used. The Smart Cabin concept aims to enhance the passenger experience by granting a new level of cabin comfort, customization and connectivity that allows the reduction of airplane time on ground because of the real-time monitoring of airplane cabin components that enables the prediction of maintenance procedures, creates new profits and revenues opportunities for services, provides a more sustainable airplane operation and derived services, and creates new business opportunities for all companies that integrate regional aviation ecosystem.

ABSTRACT The use of Global Navigation Satellite System (GNSS) for air and terrestrial navigation and for many applications is increasing in the last decades. However, the Earth’s ionosphere causes GNSS signal delay due to the total electron content (TEC) and scintillation in the signal phase and amplitude. This scintillation can give rise to deleterious effects in the GNSS positioning. So, it is important to assess the effects of the ionosphere over the GNSS signal. To achieve this goal, it is necessary to have a large spatial and temporal coverage of data from many different sounders, being the GNSS receivers of great importance due to their global coverage and availability. In this work, we present a retrospective of the scintillation monitoring networks in Brazil and their characteristics. As the RBMC network managed by the IBGE provides TEC and as rate of TEC index (ROTI) is well correlated with ionospheric irregularities, we present also the RBMC network description. These RBMC GNSS receivers provide data in regions with scarcity of scintillation monitors. The description of the Ionospheric Scintillation Monitoring Receivers (ISMR) Query Tool, that is a web software that has been supporting research on the ISMR data, is also presented. (GNSS decades However Earths Earth s (TEC amplitude positioning So goal sounders availability work characteristics ROTI (ROTI irregularities monitors (ISMR Tool presented

Abstract Introduction The increase in sedentary screen time can negatively affect the quality of sleep, impacting the performance of daily activities. Objective To analyze the association between sedentary screen time and sleep quality, regardless of the symptoms of anxiety in adolescents of both genders. Method Cross-sectional study integrating school-based epidemiological research with a representative sample (n = 666) of high school students (14 to 19 years old) in public schools in the municipality of Caruaru-PE. The translated versions into Portuguese of the Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale (HAD) were applied to analyze sleep quality and anxiety, respectively. Binary logistic regression was used to analyze the association, considering sleep quality as an outcome. Results There was a positive, statistically significant (p< .001) correlation between sleep quality and symptoms of anxiety (r = .393). A significant association regarding the association between screen time and sleep quality was noted only in those adolescents classified as being possible or probable anxiety cases and only in exposure to the computer (OR = 2.337; 95% CI [1.01, 5.43]) and video games (OR = 8.083; 95% CI [2.0, 32.8]) after adjusting for gender, age, and school shift. Discussion and conclusion Increased interaction with the screen and higher levels of anxiety can be more harmful to sleep in adolescents. Exposure to screen time, specifically those which have a greater interaction such as video games and computers, can have a negative impact on sleep quality, but only in adolescents with a higher risk of anxiety.

Resumen Introducción Un elevado tiempo de exposición de pantalla puede afectar tanto la calidad del sueño como las actividades diarias. Objetivo Analizar la asociación entre el tiempo de pantalla sedentario y la calidad del sueño, independientemente de los síntomas de ansiedad en adolescentes de ambos sexos. Método Estudio transversal que integra la investigación epidemiológica escolar con una muestra representativa (n = 666) de estudiantes (14 a 19 años) de escuelas públicas de Caruaru-PE. Las versiones traducidas al portugués del Índice de Calidad del Sueño de Pittsburgh (PSQI) y la Escala de Ansiedad y Depresión Hospitalaria (HAD) se aplicaron para analizar la calidad del sueño y la ansiedad. Se utilizó regresión logística binaria para analizar la asociación, considerando como resultado la calidad del sueño. Resultados Hubo una correlación positiva y estadísticamente significativa (p< .001) entre la calidad del sueño y los síntomas de ansiedad (r = .393). Una asociación significativa en cuanto a la asociación entre el tiempo de pantalla y la calidad del sueño se observó sólo en adolescentes clasificados como casos posibles o probables de ansiedad y sólo en la exposición al ordenador (OR = 2.337; IC 95% [1.01, 5.43]) y videojuegos (OR = 8.083; 95% IC [2.0, 32.8]) después de los ajustes. Discusión y conclusión Una mayor interacción con la pantalla y altos niveles de ansiedad pueden ser perjudiciales para el sueño. La exposición al tiempo de pantalla, específicamente aquellos con mayor interacción, como los videojuegos y las computadoras, puede afectar negativamente la calidad del sueño, pero sólo en adolescentes con mayor riesgo de ansiedad.

RESUMO A cebola para produzir bulbos ou sementes depende da interação do genótipo com o ambiente. Assim, programas de melhoramento genético devem realizar a seleção com base nas condições climáticas de cada região produtora. Neste estudo, objetivou-se avaliar 17 híbridos experimentais de cebola e dois genótipos comercias (‘Bella Dura’ e ‘Buccaneer’) com base em atributos agronômicos, físico-químicos dos bulbos e de resistência ao florescimento precoce em condições subtropicais. Foi realizada análise de variância conjunta e a divergência fenotípica estimada por meio de análise de componentes principais (PCA) e agrupamento hierárquico de Ward. Observou-se que a época de transplante afetou mais as características agronômicas do que as características físico-químicas, não afetando a porcentagem de florescimento precoce dos genótipos. O transplantio de primeira época propiciou maiores produtividades de bulbos, enquanto, o transplante na segunda época, reduziu o ciclo e a produtividade. Os híbridos H1, H17 e ‘Buccaneer’ tiveram taxa de florescimento inferior a 3%. Entre os híbridos experimentais, H2 apresentou produtividade superior às cultivares comercias e, H1, H12 e H14 foram equivalentes a estas. No entanto, o H12 apresentou maior índice de florescimento precoce (43%). Assim, dentre os genótipos experimentais avaliados sob condições subtropicais, H1, H2, e H14, demonstraram potencial de uso comercial ou mesmo como potenciais genitores no avanço do programa de melhoramento, pois se destacaram por apresentar bom rendimento produtivo, qualidade de bulbo e baixo percentual de florescimento precoce.

ABSTRACT In order to produce bulbs or seeds, onion plants depend on genotype X environment interaction. Thus, breeders shall select the genotypes based on the climatic conditions of each producing region. This study aimed to evaluate 17 experimental onion hybrids and two commercial genotypes (‘Bella Dura’ and ‘Buccaneer’), based on agronomic, physicochemical attributes of the bulbs and resistance to early flowering under subtropical conditions. Joint analysis of variance and phenotypic divergence estimated through principal component analysis (PCA) and Ward’s hierarchical clustering were performed. We observed that the time of transplantation affected the agronomic traits more than the physicochemical traits, not affecting the percentage of early flowering of the genotypes. The first transplant season provided higher bulb productivity, whereas the second season reduced the cycle and productivity. Hybrids H1, H17 and ‘Buccaneer’ showed flowering rate lower than 3%. Among the experimental hybrids, H2 showed higher productivity when comparing with commercial cultivars, and H1, H12 and H14 were equivalent to them. However, H12 showed the highest early flowering rate (43%). Thus, considering the experimental genotypes evaluated under subtropical conditions, H1, H2, and H14, showed potential for commercial use or as potential parents in advancing the breeding program, as they stood out for presenting good yield, bulb quality and low percentage of early flowering.

ABSTRACT The quest for resistance sources against Meloidogyne incognita as a control measure is essential in tomato. Thus, this study aimed to evaluate the reaction of six species of wild solanaceae to M. incognita. The species of wild solanaceae studied were Solanum capsicoides, S. asperolanatum, S. americanum, S. viarum, S. palinacanthum and Nicandra physaloides. Seedlings of wild solanaceae species were transplanted and inoculated with M. incognita. The experiment was performed in a completely randomized design with eight replicates. The analyzed variables were: height of the aerial portion, fresh weight of the aerial portion, fresh weight and length of the root system, gall index, number of galls/g of root, number of egg masses/g of root, number of eggs/g of root and the nematode reproduction factor. Based on gall index and reproduction factor criteria the species S. capsicoides, S. americanum, S. palinacanthum and N. physaloides were classified as resistant against M. incognita. These species also showed a significant increase in height and fresh weight of the aerial portion, length of the root system and fresh weight of the root system. Therefore, these species of wild solanaceae may contribute to the management of M. incognita in future applications.

Abstract The present study aimed to determine the prevalence of negative self-perception in health as well as to verify if there is an association with modifiable health risk behaviors in adolescents. Methods: This is a cross-sectional, analytical and school-based study carried out with high school students of the state public network of the municipality of Olinda-PE. Information regarding modifiable risk behaviors was obtained from the Youth Risk Behavior Survey (YRBS). Self-perception of health was measured from a single question in which adolescents self-reported their health status and were classified as negative self-perceived adolescents who chose the alternatives "unhealthy and not very healthy." The data were tabulated by the Epi-data version 3.1 program and analyzed in SPSS version 22. The Chi-square test (p <0.05) was used and stepwise binary logistic regression was performed to analyze the associated factors (α = 0.05). Results: The prevalence of negative self-perception in health was 26.7% (32.9% for girls and 19.1% for boys p <0.001). The modifiable behaviors associated with negative self-perception in health were: Use of tobacco; alcohol use; use of marijuana and not participating in sports teams (p <0.05). In the regression model adjusted for sex and age, the use of alcohol and tobacco remained associated with negative self-perception in health. Conclusion: The negative self-perception in health was a sign of modifiable health behaviors. Adolescents who negatively evaluated their health presented higher percentages of tobacco and alcohol use.

Resumo O presente estudo teve como objetivo determinar a prevalência da autopercepção negativa em saúde bem como verificar se existe associação a comportamentos de risco modificáveis a saúde em adolescentes. Trata-se de um estudo transversal, analítico e de base escolar, realizado com alunos do ensino médio da rede pública estadual do município de Olinda-PE. As informações referentes aos comportamentos de risco modificáveis foram obtidas a partir do questionário “Youth Risk Behavior Survey” (YRBS). A autopercepção de saúde foi mensurada a partir de uma única pergunta no qual os adolescentes autoreferiam o seu estado de saúde e foram classificados em autopercepção negativa os adolescentes que optaram pelas alternativas “nada saudável e não muito saudável”. Os dados foram tabulados pelo programa Epi-data versão 3.1 e analisados no SPSS versão 22. Foi utilizado o teste do Qui-quadrado (p<0,05) e realizou-se regressão logística binária stepwise para analisar os fatores associados (α=0,05). A prevalência da autopercepção negativa em saúde foi de 26,7% (32,9% para as moças e 19,1% para os rapazes p<0,001). Os comportamentos modificáveis associados à autopercepção negativa em saúde foram: Uso de tabaco; uso de álcool; uso de maconha e não participar de equipe esportiva (p<0,05). No modelo de regressão ajustada por sexo e idade, o uso de álcool, tabaco permaneceu associado à autopercepção negativa em saúde. A autopercepção negativa em saúde apresentou-se como um sinalizador de comportamentos de risco modificáveis a saúde. Adolescentes que avaliaram negativamente sua saúde apresentaram maiores percentuais de uso de tabaco e álcool.

ABSTRACT Among the less exploited Brazilian native fruit trees, the Spondias dulcis (cajá-manga) has many uses, being their fruits appreciated in fresh consumption and its pulp used in popsicles, ice-creams, and jellies production. However, there is a lack of research on this species, being necessary more studies. This work aimed to characterize the physical and chemical quality and the genetic diversity of Spondias dulcis fruits harvested in different accessions in the municipality of Jataí - GO. The experiment was carried out in a completely randomized design with six treatments (accessions), ten replications with ten fruits per plot, totaling a sample of 600 fruits. The fruits were evaluated for pulp and peel color, pulp yield, soluble solids content, titratable acidity, soluble solids content/titratable acidity ratio, and vitamin C content. The fruits from accessions M4 and M5 presented physical and chemical characteristics higher than the other plants. The evaluated accessions presented genetic variability, being the methodology employed efficiently to indicate this variability, in which the accession M2 was the most divergent.

ABSTRACT The air traffic environment is a complex system that involves several players. Between the air navigation service provider (ANPS) and the final client, many different organizations act with different purposes but are strongly interfaced. Changes and modifications in terms of technology, predefined process, or personnel are constantly needed, requiring coordination among the stakeholders. However, due to the high level of interaction between the players, any change in a complex system like the air traffic environment requires risk management. This paper demonstrates the suitability and advantages of the System-Theoretic Accident Model and Processes/Systems-Theoretic Process Analysis (STAMP/STPA) method to be applied to the risk assessment of an operational air traffic modification. The method, which had never been used on an air traffic problem in Brazil before, was applied considering the implementation of segregated simultaneous operation at the Guarulhos International Airport. The results were proven to be effective in terms of deriving useful safety requirements. From such demonstration, STAMP/STPA can be considered as a feasible alternative to the brainstorming method currently applied for risk assessment and generation of safety requirements regarding modifications in the structure of the air traffic services (ATS) in Brazil.

ABSTRACT Air navigation is increasingly dependent on the use of Global Navigation Satellite Systems (GNSS). It allows the determination of the aircraft’s position in all phases of the flight and brings many advantages. Although GNSS navigation results in gains, the radio signals from these systems are strongly influenced by the ionospheric environment. It introduces errors that can affect the accuracy, integrity, availability and continuity requirements established by the International Civil Aviation Organization (ICAO). The ionospheric layer has different behaviors depending on the latitude, time of day, season of the year, geomagnetic activity and solar cycle. Since Brazil is located in a region of low latitudes, it experiences a series of unique challenges when compared to regions of mid-latitudes. For this reason, the application of GNSS-based technologies in aviation over the Brazilian territory requires an in-depth assessment of the ionosphere effects. Therefore, the Instituto Nacional de Ciência e Tecnologia (INCT) named GNSS Technology for Supporting Air Navigation was formed in 2017 to better assess the ionosphere impacts and assist government agencies and companies in the development of safe air navigation procedures over Brazil in a near future. This paper presents the most relevant advances achieved so far within this multidisciplinary project that involves Brazilian research centers and universities.

Resumo: Os principais objetivos deste artigo são: verificar se a alta fragmentação da representação política na Câmara dos Deputados ocorre também no Senado Federal, nos Executivos estaduais e nas prefeituras das capitais; e se a fundação de novos partidos retirou dos “tradicionais” o controle sobre postos relevantes de poder, abrindo espaço para políticos sem carreiras políticas consolidadas conquistarem tais posições. Empreendeu-se uma análise da distribuição partidária de 27 governos estaduais, 26 prefeituras de capitais e das 81 cadeiras no Senado. Tal mapeamento permite comprovar que os cargos majoritários se encontraram, ao longo dos anos de 1994 a 2016, fechados para um pequeno número de legendas “tradicionais” (PMDB, PSDB, PT e DEM) e políticos em circulação por postos majoritários.

Abstract: The main purpose of this article is to verify if the high fragmentation of political-party representation identified in the lower house of the Brazilian parliament also occurs in non-proportional elections to the Federal Senate, state executive branches and the city halls of state capitals. In addition, the article explores whether the founding of new parties diminishes the control of traditional parties over relevant power positions and if the creation of these new channels for political competition helps non-career politicians gain access to such positions. To answer those questions, we analyzed the partisan distribution of 27 state governments, 26 states capital city halls and the 81 seats in the Senate between 1994 and 2016. This mapping allows us to demonstrate that these majoritarian electoral seats were open to only a small number of “traditional” parties - PMDB, PSDB, PT and DEM, whose politicians circulated from post to post.

This study describes a virtual screening performed for two series of selenides (28 compounds), derived from N-phenylacetamides chlorides and 7-chloro-quinoline, to determine their potential for leishmanicidal activity against Leishmania amazonensis and Leishmania donovani. Seven compounds were predicted as potential leishmanicides; therefore, they were synthesized from elemental selenium, as a precursor for the production of NaHSe, and subsequent reactions with 4,7-dichloro-quinoline and N-phenylacetamides chlorides were performed. The compounds were characterized by infrared (IR), 1H and 13C nuclear magnetic resonance (NMR), and sent for in vitro cytotoxicity tests against L. amazonensis and were found to be active and selective, and two compounds presented half-maximal inhibitory concentrations (IC50) of 5.67 and 10.81 µg mL-1. They also presented good interaction energies in the docking study, suggesting that may exert their effects by inhibiting the N-myristoyltransferase and O-acetylserine sulfhydrylase enzymes in parasites.